IJIMS.2017.106

Type of Article: Original Research

Volume 4; Issue 4: 2017

Page No.: 484-486

DOI: 10.16965/ijims.2017.106

 

HbA1c as a screening biomarker of dyslipidemia in Type 2 Diabetes mellitus patients

S L Sharma 1 , Jigar Shaherawala *2, Ketan mangukiya 3.

1 Associate Professor, Department of biochemistry, Smt NHL MMC, Ahemdabad, Gujarat, India.

*2 Assistant Professor, Department of biochemistry, Smt NHL MMC, Ahemdabad, Gujarat, India.

3 Assistant Professor, Department of biochemistry, Parul Institute of medical  science and  Research, Vadodara, Gujarat, India.

Address for Correspondence: Dr Jigar Shaherawala E-101 Maruti heritage, b/h Maruti Plaza, Sardarchowk road, Vijaypark, Krishnanagar, Ahmedabad, Gujarat, India.

E-Mail: Jigarshaherawala11111 @gmail.com

ABSTRACT

Background: Diabetes mellitus is a disease of the pancreas, an organ behind your stomach that produces the hormone insulin. Insulin helps the body use food for energy. Blood sugar level is found to be high in Diabetes mellitus.

Aim: The Aim is to study roll of HbA1c as screening biomarker of dyslipidemia in Type 2 Diabetes mellitus patients.

Methodology: Study consists of 140 type 2 DM patients of 40-60 year age group along with age and sex matched healthy control. Fasting Blood samples were collected from all participants for measurement of Lipid profile, Blood sugar(FBS) and HbA1c .

Results: In case group ,The mean concentration of Fasting blood glucose(mg/dl), S.Cholesterol(mg/dl), S.Triglyceride(mg/dl), S.HDL(mg/dl) and HbA1c(%) is 153.2±5.2, 245.9±9.5, 210.5±5.2 30.52±6.3 and 9.7±1.0  Respectively  while in control  group it is 94.5±6, 148.3±8.5, 118.6±7.3,44.5±3.2 and 5.4±0.5 respectively.

Conclusion: There is significant positive correlation is found between HBA1C and dyslipidemia. So  HBA1C is not only a useful biomarker of long-term glycemic control but also a good predictor of lipid profile.

Key words: Dyslipidemia, HbA1c, Type 2 DM.

REFERENCES

  1. Arshag D Mooradian. Dyslipidemia in type 2 diabetes mellitus. Nature Clinical Practice Endocrinology and Metabolism 2009;5(3):150-59.
  2. Gimeno-Orna JA, Faure-Nogueras E and SanchoSerrano MA. Usefulness of total cholesterol/HDLcholesterol ratio in the management of diabetic dyslipidaemia. Diabet Med 2005;22:26-31.
  3. Anjana RM, Pradeep R, Deepa M, et al Prevalence of diabetes and prediabetes(Impaired fasting glucose and /or impaired glucose tolerance ) in urban and rural india :phase 1 results of the Indian Council of Medical Research –Indian Diabetes(ICMR=INDIAB) study:Diabetologia 2011;54(12):3022-7.
  4. Chandramohan P,Mohan V. High prevalence of Diabetes and Metabolic Syndrome Among policeman JAPI NOV.2008;56:837-38.
  5. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
  6. Peterson KP, Pavlovich JG,Goldstein D,Little R, England J,Peterson CM.What is hemoglobin A1c ?An analysis of Glycated hemoglobins by electospray ionization mass spectrometry.Clin Chem.1998,2008;44(9):1951-8.
  7. Rosediani M, Azidah AK, Mafauzy M. Correlation between fasting plasma glucose, post prandial glucose and glycated haemoglobin and fructosamine. Med J Malaysia 2006;61:67-71.
  8. Sultan A,Thuan JF,Avignon A.Primary Prevalence of cardiovascular events and type 2 diabetes should we prioritize our interventions?Diabetes Metab.2006;32:559-567.
  9. Selvin E,Marinopoulos S,Berkenblit G,Rami T,Brancati FI,Powe NR.Metaanalysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus.Ann Intern Med 2004;14:421-431.
  10. Erclays F,Taneli F,Arslan B and Uslu Y.glycemic control,oxidative stress and lipid profile in children with type 1 diabetes mellitus. Arch. Med. Res 2004;35:134-140.
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