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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2016.104

Type of Article: Review

Volume 3; Issue 2: February 2016

Page No.: 225-228

DOI: 10.16965/ijims.2016.104

 

Controversies on Preeclampsia through the lens of Reproductive Immunology: A Systematic Review

Seyyed Amir Yasin Ahmadi 1, Farhad Shahsavar 2, Afshin hasanvand *1

*1 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

2 Associate Prof of immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.

CORRESPONDING AUTHOR ADDRESS: Afshin Hasanvand, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. E-Mail: afshinhasanvand@yahoo.com­

ABSTRACT

Preeclampsia which is a kind of pregnancy specific syndrome, is the major cause of maternal and perinatal morbidity and mortality with an incidence of 5-8% of all pregnancies worldwide. Since the exact etiology of preeclampsia is still unknown, there are some controversial issues that we are trying to solve them in present systematic review. Failure of arterial remodeling in endometrium results in inadequate blood supplying of the fetus and preeclampsia and the controversies are mainly about involving immunological mechanisms. The solution of such controversies is to write meta-analysis for future papers and also genetic-polymorphism-wise screening of immunologic molecules in future original researches. Further research is suggested to solve the controversies.

Key words: Preeclampsia, HELLP Syndrome, Reproductive Immunology, Natural Killer Cell.

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