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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2016.106

Type of Article: Review

Volume 3; Issue 2: February 2016

Page No.: 229-231

DOI: 10.16965/ijims.2016.106

 

Vascular Endothelial Growth Factor (VEGF) and Its Controversies about Nephrotic Syndrome and Diabetic Nephropathy: A Systematic Review

Seyyed Amir Yasin Ahmadi 1, Pary Sadat Ahmadi 2, Majid Tavafi 3, Afshin hasanvand *1

*1 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

2 General Practitioner, Iran University of Medical Sciences, Tehran, Iran.

3 Department of Anatomy, Lorestan University of Medical Sciences, Khorramabad, Iran.

CORRESPONDING AUTHOR ADDRESS: Afshin Hasanvand, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. E-Mail: afshinhasanvand@yahoo.com­

ABSTRACT

Variety of immune factors such as interleukins are involved with nephrotic syndrome. Circulating permeability factors also might be effective. But among them there is a controversy about the vascular endothelial growth factor (VEGF) that seems to have paradoxical effects on diabetic nephropathy and nephrotic syndrome. We want to announce that we have significant increasing of VEGF rate in diabetic nephropathy and in nephrotic syndrome we have increasing in VEGF rate but not significant. Our hypothesis is that this increasing of VEGF is not the reason of nephrotic syndrome; rather, it might be a compensatory regulation to repair endothelial injury.

Key words: Nephrotic Syndrome, Diabetic Nephropathy, VEGF.

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