https://imedsciences.com/ editor_ijims@hotmail.com
ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2016.127

Type of Article: Original Research

Volume 3; Issue 6: June 2016

Page No.: 312-317

DOI: 10.16965/ijims.2016.127

Effect of Indigenous Drug Administration (KARELA) on Different Parameters Studied Among Healthy and NIDDM Subjects: A Hospital Based Study

Parul Gupta *1, Ajay kumar Srivastava 2.

*1 Ph.D. Scholar, Department of Biochemistry, GSVM medical college, Kanpur (UP), India.

2 Professor and Head, Department of Biochemistry, GSVM medical college, Kanpur (UP), India.

CORRESPONDING AUTHOR ADDRESS: Dr. Parul Gupta, Ph.D. Scholar, Department of Biochemistry, GSVM medical college, Kanpur (UP), India. Mobile no.: +919956305882, E-Mail: parul2080@gmail.com

ABSTRACT

Background: Diabetes mellitus is a group of metabolic disorders with one common manifestation: hyperglycaemia. Chronic hyperglycaemia causes damage to the eyes, kidneys, nerves, heart and blood vessels. The rationale behind this study is to see the effect of Momordica charantia on different carbohydrate and oxidative stress parameters in blood/ serum and to correlate its effect on these parameters among diabetic patients.

Objectives- 1. To see the effect of Momordica charantia on different carbohydrate and lipid parameters in blood/ serum   2. To correlate its effect on these parameters among diabetic patients.

Materials and Methods: It was a hospital based prospective study conducted for a period of 8 months from September 2013- April 2014 in LLR hospital and diabetic clinic of GSVM medical college, Kanpur (UP). A total of 180 study participants were included in the study which consists of 90 diabetic patients and 90 healthy individuals. The investigation reports were collected from pathology laboratory of the college for both diabetic and normal subjects. The parameters which were studied includes plasma glucose levels, glycosylated hemoglobin (HbA1c), catalase, gluthatione peroxidase.before conducting the study prior consent of the subjects is taken. Selected subjects were advised to take medicinal plants/substances (karela) from last one month of the study to see its effect. Epi-info software was used. And both paired and unpaired student‘t’ test were applied for analysis.

Conclusion: present study showed a significant change in plasma glucose level and increasing anti-oxidant activity which counteracts hyperglycemia when karela drug powder was administrated. Observation suggest that Karela posses the hypoglycaemic effect.

Key words: Diabetes, Hyperglycemia, Momordica Charantia.

REFERENCES

  1. American Diabetes Association (ADA): Clinical Practice Recommendations 2013. report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care Volume 24, Supplement 1, 2013.
  2. Diabetes Care, Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. 1997;20(7):1183-97.
  3. International Diabetes Federation. Diabetes e-Atlas. [July 14]. Available at: http://www.eatlas.idf.org. 2005.
  4. Kasper, Braunwald, Fauci, Hauser, Longo & Jameson. Harrison’s “Principles of Internal Medicine”. Chapter 323 Diabetes Mellitus (Alvin C. Powers). Page. 2152, 2176. 16th edition 2004.
  5. St Louis, Mo., Wolters Kluwer, Facts and Comparisons: The Review of Natural Products,1999.
  6. Lancet; Booth GL, et al. Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. 2006;368:29-36.
  7. Khanna P, Jain SC, Panagariya A, Dixit VP: Hypoglycemic activity of polypeptide-p from a plant source. J Nat Prod 1981;44:648-655.
  8. Ahmed N, Hassan MR, Halder H, Bennoor KS: Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose level in NIDDM patients. Bangladesh Med Res Counc Bull 1999;25:11-13.
  9. Sathishsekar D, Subramanian S. Antioxidant properties of Momordica Charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats. Department of Biochemistry and Molecular Biology, University of Madras, Chennai-25, India; 2005
  10. Asli SEMIZ and Alaattin SEN Antioxidant and chemoprotective properties of Momordica charantia (bitter melon) fruit extract Department of Biology, Pamukkale University, 20070 Kinikli-Denizli, TURKEY. Accepted 5 January, 2007
  11. Mona, Kumar A, et al. “Biochemical studies on the status of free radical and scavangers of some of the bioactive natural products against urolothiasis”, Ph.D. Thesis, University of Kanpur, 2001
  12. Miura, T., Itoh, C., Iwamoto, N., Kato, M., Kawai, M., Park, S. R. and Suzuki, I., Hypoglycemic activity of the fruit of Momordica charantia in type 2 diabetic mice. Nutr. Sci. Vitaminol. (Tokyo), 2001;47:240-244.
  13. Pawa M, MSc(London), MBA(HSM), MBBS, FRSM Use of traditional/herbal remedies by Indo-Asian people with type 2 diabetes; Fieldway Medical Centre, Fieldway, New Addington, Croydon, UK, 4 April 2005.
  14. Tongia, A., Tongia, S. K. and Dave, M., Phytochemical determination, and extraction of Momordica charantia fruit and its hypoglycaemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM). Indian J. Physiol. Pharmacol., 2004;48:241-244.
  15. Shetty, A. K., Kumar, G. S., Sambaiah, K. and Salimath, P. V., Effect of bitter gourd (Momordica charantia) on glycemic status in streptozotocin induced diabetic rats. Plant Foods Hum. Nutr. 2005;60:109-112.
  16. Senanayake GV, Maruyama M, Sakono M, Fukuda N, Morishita T, Yukizaki C, Kawano M, Ohta H. The effects of bitter melon (Momordica charantia) extracts on serum and liver lipid parameters in hamsters fed cholesterol-free and cholesterolenriched diets. Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan, 2005.
  17. Yadav UC, Moorthy K, Baquer NZ. Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats. Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India; 2004.
  18. WHO Expert Committee on Diabetes Mellitus: second report. World Health Organ Tech Rep Ser 2012;646:1-80.

Download Full Text TOC