https://imedsciences.com/ editor_ijims@hotmail.com
ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2016.138

Type of Article: Original Research

Volume 3; Issue 7: July 2016

Page No.: 353-360

DOI: 10.16965/ijims.2016.138

Cardiovascular Symapthetic Changes In Type-II Diabetics

K. Praveena Kumari *1, P. Vijitha 2, Nazia Farha 2, M. Neeraja 2.

*1 Senior resident, A.C.S.R Government Medical College, Nellore, Andhra Pradesh, India.

2 Assistant professor, A.C.S.R Government Medical College, Nellore, Andhra Pradesh, India.

CORRESPONDING AUTHOR ADDRESS: Dr. K. Praveena Kumari, Senior resident, Department of Physiology, A.C.S.R Government Medical College, Nellore, Andhra Pradesh, India. E-Mail: dr.praveena21@gmail.com

ABSTRACT

Involvement of nervous system is a well-known complication of diabetes. Neuropathy is one of the most common complications of diabetes. At an early stage autonomic dysfunction may be asymptomatic or mildly symptomatic. Symptomatic autonomic neuropathy carries worst prognosis, so early diagnosis is essential for maximum benefit. This study was taken up with to assess the functional status of cardiovascular sympathetic function in normal subjects and type-II diabetics of both the sexes. Quantitative sympathetic function tests were performed in 100 subjects, 50 of them were diabetics comprising the test group and 50 were non diabetic patients as control group. Descriptive statistical analysis and Students t- test was applied to test the significance of changes in cardiovascular sympathetic function. There was a statistically significant alternation in ANS functions in the test group when compared to control group. Sympathetic cardiovascular responses were altered significantly. Decreased blunted BP responses are associated with CAN in type II diabetes suggesting that impairment of sympathetic function. DM affects cardiovascular sympathetic function adversely through various metabolic and vascular mechanisms.

Key words: Sympathetic, Cardiovascular, Heart rate, Diabetes.

REFERENCES

  1. Luiz Clemente Rolim, Jose Sergio Tomaz de Souza, and Sergio Atala Dib. Tests for Early Diagnosis of Cardiovascular Autonomic Neuropathy: Critical Analysis and Relevance. Front Endocrinol (Lausanne). 2013;4:173.
  2. Diagnosis and Classification of Diabetes Mellitus American Diabetes Association. Diabetes Care.2014:37;1.
  3. Gerasimos Dimitropoulos,Abd A Tahrani, and Martin J Stevens. Cardiac autonomic neuropathy in patients with diabetes mellitus World J Diabetes. 2014:15;5(1):17–39.
  4. Mudassir Mirza and A.N.R.Lakshmi. A comparative study of heart rate variability in diabetic subjects and normal subjects; IJBAR;2012;03(08).
  5. Oakley I,Emond L. Diabetic cardiac autonomic neuropathy and anesthetic management: review of the literature. AANA J. 2011;79(6):473-9.
  6. Samy M. Makary, Hamdy A. Selim’, Yasser M. El-Wazir, Abd El-Ariz Mahmoud. Physiological Assessment of Cardiac Autonomic Reflexes in Diabetics. Suez Canal Univ Med J, March, 1999;2:I6-72.
  7. Alexandra diana comanescu. Subclinical diagnosis of cardiovascular autonomic neuropathy in type 2 diabetes: prevalence, severity, correlations with time, metabolic and vascular factors. Romanian journal of neurology; 2010:ix:1.
  8. AK Basu, R Bandyopadhyay, S Chakrabarti, R Paul, S Santra. A Study on The Prevalence of Cardiac Autonomic Neuropathy in Type-2 Diabetes in Eastern India. JIACM 2010;11(3):190-4.
  9. Bennett T, Hosking D.J and Hampton J.R. Cardiovascular control in diabetes mellitus. British Medical journal. 1975;2:585-7.
  10. Bandi Hari Krishna, Mallikarjuna Reddy N, Sharan B, Singh M, Sasi Kala P, Kiran Kumar C H, Uma B V, Vijetha P, Shravya Keerthi G; Cardiovascular autonomic neuropathy in diabetics: Correlation with duration of diabetes. Biomed Res- India Volume 25 Issue 3.
  11. Khairul Alam Noorzahan Begum, M.H.Molla,Shelina Begum. A study of Sympathetic nerve function status in type2 diabetes-relationship with glycemic status and duration. 2008:11:1.
  12. Ewings D.J. cardiovascular reflexex and autonomic neuropathy. Clinical Science and Molecular Medicine. 1978;55(4):321-7.
  13. Valensi P, Huard J.P, Giroux C, Attali J.R; Factors involved in cardiac autonomic neuropathy in diabetic patients. J Diabetes complications. 1997;11(3):180-7.
  14. David j. Ewing,Christopher N. Martyn, Robert J. Young And basil f. Clarke;The value of cardiovascular autonomic function tests:10 years experience in diabetes;diabetes care, september-october 1985:8:5.
  15. Nanda R. Chavan, Salim A. Dhundasi and Kusal K. Das; Determination of sensitivity among various cardiovascular autonomic function tests in diabetic patients of Bijapur. Journal of Basic & Clinical Physiology & Pharmacology. 2009;20:2.
  16. I.Velchevaa, P. Damianova, St. Mantarovab, N. Antonovac; Cold pressor test: Effects on cardiac autonomic control and cerebral hemodynamic response in patients with diabetes mellitus type 2: Series on Biomechanics. 2012:27(1-2);64-9.
Download Full Text TOC