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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2016.141

Type of Article: Original Research

Volume 3; Issue 8: August 2016

Page No.: 374-383

DOI: 10.16965/ijims.2016.141

Cardiovascular Parasympathetic Changes in Type-II Diabetic Mellitus

K. Praveena Kumari *1, M. Neeraja 2, S. Chandan Kumar 3, Nazia Farha 2, P. Vijitha 2.

*1 Assistant Professor in Dept of Physiology Katuri medical College, Guntur, Andhra Pradesh, India.

2 Assistant Professor, A.C.S.R Government Medical College, Nellore, Andhra Pradesh, India.

3 Senior Resident in General Surgery, Melmaruvathur Adiparasakthi Institute of Medical Sciences, Melmaruvathur, Tamilnadu, India.

CORRESPONDING AUTHOR ADDRESS: Dr. Praveena Kumari MD Physiology, Assistant Professor in Dept of Physiology Katuri Medical College, Guntur, Andhra Pradesh, India. E-Mail: dr.praveena21@gmail.com

ABSTRACT

Objectives: To evaluate cardiovascular parasympathetic function tests in diabetes and match the data so obtained with healthy non diabetic individuals as controls.

Materials and Methods: Present prospective study was conducted in the department of physiology, Siddhartha medical college and govt.gen.hospital, Vijayawada during October 2012 to September 2014. Total 100 subjects were selected which includes 50 randomly selected population and also 50 type-II diabetics who are diagnosed based on WHO criteria. The exclusion criteria were patients taking medications other than oral hypoglycemics that could influence the autonomic functions and drugs those could affect the cardiovascular functions are excluded.

Results: The mean ± SD of Age of group-A and group-B were found to be: group-A : 50.26 ± 5.27, group-B cases: 49.32 ± 5.83 respectively. HR response to standing of group-A and group-B were 1.14 ± 0.13 and 1.08 ± 0.11 respectively. HR in response to deep breathing test group-A and group-B of were 25.5 ± 6.96 and 19.12 ± 9.41 respectively. HR in response to Valsalva manoeuvre of group-A and group-B were 1.39 ± 0.24 and 1.24± 0.13 respectively.

Conclusion: There was a statistically significant alternation in ANS functions in the test group when compared to control group. Both parasympathetic and sympathetic cardiovascular responses were altered significantly. Decreased HRV are associated with CAN in type II diabetes suggesting that impairment of autonomic function. DM affects cardiovascular autonomic function adversely through various metabolic and vascular mechanisms.

Key Words: Parasympathetic, Cardiovascular, Heart rate, Diabetes.

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