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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2016.151

Type of Article: Original Research

Volume 3; Issue 9: September 2016

Page No.: 419-425

DOI: 10.16965/ijims.2016.151

Effect of Prophylactic Bromfenac 0.07% on Cystoid Macular Edema Assessed using Optical Coherence Tomography Quantification of Total Macular Volume after Cataract Surgery

Vankadara Naga Suresh *1, Rama Vadapalli 2.

*1 Associate Professor, Department of Ophthalmology, Viswa Bharathi Medical College, Kurnool, Andhra Pradesh, India.

2 Assistant Professor, Department of Ophthalmology, Santhiram Medical College, Nandyal, Andhra Pradesh, India.

CORRESPONDING AUTHOR ADDRESS: Dr. V. Naga Suresh, Associate professor, Department of Ophthalmology, Viswa Bharathi Medical College, Kurnool, Andhra Pradesh, India. E-Mail: drnagasuresh@gmail.com

ABSTRACT

Objective(s): To evaluate the efficacy of prophylactic administration of the topical nonsteroidal anti-inflammatory drug (NSAID) Bromfenac 0.07% on acute (within 4 weeks of surgery) cystoid macular edema (CME) and total macular volume (TMV) in patients having phacoemulsification cataract surgery.

Materials and Methods: This open-label non-masked randomized (random number assignment) study comprised 100 eyes. Exclusion criteria Included hypersensitivity to the NSAID drug class, aspirin/NSAID-induced asthma, and pregnancy in the third trimester. Bromfenac 0.07%was administered starting 1 day before surgery and for 28 days after surgery for a total of 30 days. The outcome measure was macular swelling, which was quantified by the optical coherence tomography.

Results: At 1 month, there was a statistically significant difference in TMV between the control group (0.4420 mm3) and the Bromfenac 0.07%group (0.2392 mm3), with the Bromfenac 0.07%group having 45.8% less macular swelling (P Z .009). Multiple linear regression with backward selection indicated a 44.3% (P Z .013) and 46.1% (P Z .030) reduction in macular swelling in the Bromfenac 0.07% group at 1 week and 1 month, respectively.

Conclusion: Used prophylactically after cataract surgery, Bromfenac 0.07% was efficacious in decreasing postoperative macular edema.

Key words: Prophylactic, Bromfenac, Cystoid Macular Edema, Phacoemulsification Cataract Surgery.

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