Type of Article: Original Research

Volume 4; Issue 5: 2017

Page No.: 488-492

DOI: 10.16965/ijims.2017.107

 

INDICES OF OXIDATIVE STRESS AND LIVER INJURY IN ALCOHOLIC LIVER DISEASE

Pinky Garg *1, Saroj Choudhary 2, Montosh Chakraborty 3, Karthikeyan P 4.

*1 Associate Professor, Department of Biochemistry, NDMC Medical college, Delhi, India

2 Assistant Professor, Department of Biochemistry, NDMC Medical college, Delhi, India

3 Assistant Professor, Department of Biochemistry, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair, India.

4 Senior Resident, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Address for correspondence: Dr. Pinky Garg, Associate Professor, Department of Biochemistry, NDMC Medical College, Delhi, India. E-Mail: dr.pinky18@gmail.com

ABSTRACT

Background: Alcohol is the most common substance of abuse causing alcoholic liver disease (ALD) becoming the major public health problem worldwide. During metabolism of alcohol in the liver reactive oxygen species (ROS) are generated which cause lipid peroxidation leading to hepatotoxicity. The body’s natural antioxidant defense system against free radicals is depleted by alcohol consumption.

Purpose of the study: This study was designed to know how alcohol metabolism increases oxidative stress and inflicts damage to liver and decreases the efficiency of antioxidant defense system in patients of ALD.

Materials and Methods: It was a case control study of 50 patients clinically and radiologically diagnosed of ALD compared with 50 age and sex matched normal healthy controls. All the subjects were interviewed as per the proforma designed for alcoholics. This study compared lipid peroxidation product in the form of Malondialdehyde (MDA) levels and antioxidant status in the form of reduced Glutathione (GSH) levels in ALD patients with healthy controls.

Results: The results were analyzed statistically and showed that the level of MDA of cases was significantly higher (p value<0.0001) than the control group. In comparison to normal healthy persons the GSH levels of patients of ALD showed significant decrease (p value<0.0001).

Conclusion: Our results reflected increased oxidative stress in ALD and based on these findings we can explain beneficial role of antioxidant supplementation along with alcohol abstinence in delaying the progression of ALD.

Key Words: Alcoholic liver disease, Reactive oxygen species, Malondialdehyde, Glutathione.

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