https://imedsciences.com/ editor_ijims@hotmail.com
ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2017.114

Type of Article: Original Research

Volume 4; Issue 6: 2017

Page No.: 517-521

DOI: 10.16965/ijims.2017.114

 

DYSLIPIDEMIA AND ANTI-OXIDATIVE SYSTEM IN PREECLAMPTIC WOMEN AT RURAL AREA OF RAYALASEMA

Anita Ramesh Annaldasula *1, K Durgaprasad 2.

*1 Associate professor, obstetrics & Gynecology, Shanthiram Medical College, Nandyal, Kurnool, Andhra Pradesh, India.

2 Professor and head, Biochemistry, Shanthiram Medical College, Nandyal, Kurnool, Andhara Pardesh, India.

Corresponding Author: Dr. Anita Ramesh Annaldasula, Associate professor, obstetrics & Gynecology, Shanthiram Medical College, Nandyal, Kurnool, Andhra Pradesh, India. E-Mail: anitasreekanth123@gmail.com

Abstract:

Oxidative  stress  increases  during  pre-eclampsia  and  results  in increased  production  of  lipid  peroxides,  reactive  oxygen  species  and  superoxide  anion  radicals  to  cause  endothelial  injury  and  dysfunction,  platelet  and  neutrophil activation. In preeclampsia serum antioxidants are excessively utilized to counteract the cellular changes mediated by free radicals. Antioxidants, such as caroteinoids, tocopherols, and ascorbic acid, due to their capacity for scavenging free radicals and their function as inhibitors of reactive oxygen species, are lower in women with preeclampsia with this background the role of oxidative stress in the pathogenesis of preeclampsia in south Indian women. For this reason, to strengthen the existing literature, our primary objective is to assess the status of lipid peroxidation marker MDA and antioxidants such as Vitamin-C and uric acid in women with preeclampsia. This case control study was conducted at Obstetrics and Gynecology department with collaboration with Biochemistry department. 40 controls and 40 cases (preeclamptic women) were included in the pregnant who were attending regular checkup in the Obstructs and Gynecology department op. Oxidative and anti-oxidative stress in cases compared with the controls. The p-values were showing the significance difference between the normal pregnant and preeclamptic pregnant and diagrammatically represented. The imbalance between oxidative damage and antioxidant defences in pre-eclampsia leads to endothelial cell dysfunction and it appears to be a central feature in the patho-physiology of pre-eclampsia.

Key words: Preeclampsia, MDA, Uric Acid, Vit-C, Oxidative Stress, Antioxidants.

REFERENCES

  1. Morris JM, Gopaul NK, Endresen MJ, Knight M, Linton EA, Dhir S, et al. Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia. Br J Obstet Gynaecol. 1998;105(11):1195-9.
  2. Hubel CA. Oxidative Stress in the Pathogenesis of Preeclampsia. Proc. Soc. Exp. Biol. Med Review. 1999;222(3):222-35.
  3. Working Group report on high blood pressure in pregnancy: Consensus report. Working Group on High Blood Pressure in Pregnancy. National High Blood Pressure Education Program. Am J Obstet.Gynecol. 1990;163:1689-712.
  4. Halliwell B, Gutteridge JMC. Role of free radicals and catalytic metal ions in human disease; an overview. Methods in Enzymology 1990;186:1-85.
  5. Nakai A, Oya A, Kobe H, Asakura H, Yokota A, Koshino T, Araki T. Changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery. J Nippon Med Sch 2000;67(6):434–439.
  6. Potter JM, Nestel PJ. The hyperlipidemia of pregnancy in normal and complicated pregnancies. AM J Obstet Gynecol 1979;133:165-70.
  7. Walsh SC. Lipid peroxidation in pregnancy. Hypertension Pregnancy 1994;13:1-25.
  8. Hubel CA, Roberts JM, Taylor RN, Musci TJ, Rogers GM, Mc Laughlin MK. Lipid peroxidation in pregnancy: New perspectives on preeclampsia. Am. J. Obstet. Gynecol. 1989;161:1025-34.
  9. Dutta DC, Konar HL, Test Book of Obstetrics, 6t h edn. New Central Book Agency (P) Ltd. 2004;222-3.
  10. Kharb S. Vitamin E and C in pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 2000;93(1):37-9.
  11. Dursen P, Demirtas E,Bayrak A, Haken Yarli. De-creased serum paraoxonase 1 (PON1) activity: an addi-tional risk factor for atherosclerotic heart disease in pa-tients with PCOS. Human Reproduction. 2006:21(1):104-8.
  12. Lam C, Lim KH, Kang DH, Karumanchi SA. Uric acid and preeclampsia. Semin Nephrol.2005;25(1):56-60.
  13. Zhang C, Williams MA, King IB, Dashow EE, Sorensen TK, Frederick IO, Thompson ML, Luthy DA.Vitamin C and the risk of preeclampsia–results from dietary questionnaire and plasma assay. Epidemiology.2002:13(4):409-16.
  14. Kashinakunti SV, Sunitha H, Gurupadappa K, Shankarprasad DS. Lipid peroxidation and antioxidant status in Preeclampsia. Al Ameen J Med Sci.2010:3(1):38-41.
  15. Sharma JB, Sharma A, Bahadur A, Vimala N. Oxidative stress markers and antioxidant levels in normal pregnancy and preeclampsia. International journal of Gynecology and Obstretics. 2006:94;23-7.
  16. Bowen RS, Moodley J, Dutton MF, Theron AJ. Oxidative stress in pre-eclampsia. Acta Obstet Gynecol Scand. 2001;80(8):719-25.
  17. Atiba AS, Abbiyesuku FM, Niran-atiba TA , Oparinde DP, Ajose OA, Akindele RA.Free radical attack on membrane lipid andAntioxidant vitamins in the course of preeclamptic Pregnancy. Ethiop J Health Sci. 2014;24:35-42.
  18. Yoneyama Y , Sawa R, Suzuki S, Doi D, Yoneyama K, Otsubo Y, et al. Relationship between plasma malondialdehyde levels and adenosine deaminase activities in preeclampsia. Clin Chim Acta. 2002;322(12):169-73.
  19. Kamath KR, Nayak S.R. Shantharam M. Serum Uric acid level in preeclampsia and its correlation to maternal and fetal outcome. IJBR . 2014;05(01):22-4.
  20. Sagen N, Haram K, Nilsen ST. Serumurate as a predictor of fetal outcome in severe pre-eclampsia. Acta Obstet Gynecol Scand. 1984;63(1):71-5.
  21. Sayyed A, Sontakke A. Study of Lipid Peroxidation and Antioxidant Status in Preeclampsia. JKIMSU. 2013;2(2):70-76.
  22. Adiga U, D’souza V, Kamath A, Mangalore N. Antioxidant activity and lipid peroxidation in preeclampsia. J Chin Med Assoc. 2007 Oct;70(10):4358.

 

Download Full Text TOC