Type of Article: Original Research

Volume 5; Issue 1: 2018

Page No.: 555-560

DOI: 10.16965/ijims.2017.121

 

TEMPORAL PROFILE OF SERUM LEVELS OF IL-6 IN ACUTE ISCHEMIC STROKE AND ITS RELATIONSHIP WITH STROKE SEVERITY AND OUTCOME IN INDIAN POPULATION

Saroj Choudhary *1, Debashish Chowdhury 2, T.K.Mishra 3, Sarita Agarwal 4.

*1 MD (Biochemistry), Department of Biochemistry, Maulana Azad Medical College, New Delhi, India.

2 MD (Medicine), DM (Neurology), Department of Neurology, G. B. Pant Hospital, New Delhi, India.

3 MD (Biochemistry), Department of Biochemistry, Maulana Azad Medical College, New Delhi, India.

4 MD (Biochemistry), Department of Biochemistry, Maulana Azad Medical College, New Delhi, India.

Corresponding author: Dr. Saroj Choudhary, Assistant professor, Department of Biochemistry, NDMC Medical College and Hindu Rao Hospital, Delhi-110007, India.

E-Mail: dr.sarojchoudhary28aug@gmail.com

ABSTRACT:

Introduction: Acute ischemic stroke is characterized by sudden loss of blood supply to brain leading to cerebral ischemia and neurological damage.  The ischemic event causes neuroinflammation and release of inflammatory cytokines from immune cells of brain tissues. One of such cytokine is the Interleukin-6 which is released from the neuroglia cells of the brain after an acute ischemic attack.

Purpose of the study: To estimate the serum levels of IL-6 serially at various time intervals in acute ischemic stroke patients and comparing them with healthy control;  to evaluate the association of baseline serum IL-6 levels with stroke severity and outcome.

Materials and method: In 33 cases of acute ischemic stroke IL-6 was measured in serum by ELISA on the day of admission, day seventh, one month, and at third month. Severity of stroke was assessed clinically using national institute of health stroke scale (NIHSS) at day one and radiologically by infarct volume on diffusion weighted imaging (DWI) of MRI within initial seven days. The short term outcome was assessed by NIHSS at seventh day and long term outcome by modified rankin scale (MRS) at 1 month and three months. IL-6 levels were also measured in  age and sex matched 60 healthy controls.

Results:  Serum levels of IL-6 were significantly high among cases than healthy controls at all stages. Baseline IL-6 levels in cases showed a significant positive correlation with stroke severity and outcome.

Conclusion: Baseline levels of IL-6 correlates with stroke severity and predicts worse outcome on short term and long term.

Key words: Ischemic stroke, IL-6, NIHSS, MRS, Infarct volume.

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