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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2018.105

Type of Article: Original Research

Volume 5; Issue 3: 2018

Page No.: 597-601

DOI: 10.16965/ijims.2018.105

 

RELATION BETWEEN SERUM MAGNESIUM AND DIABETIC NEPHROPATHY

Ketham Veera Sudhakar *1, Mohammed Sabiullah 2, A. Padma Vijaya Sree 3, B. Vijaya Saradhini 4, P. V. Satyanarayana 5, Venateswarlu 3, Aparna 3.

*1 Department of Biochemistry, Viswabharathi Medical College & General Hospital, Kurnool, Andhra Pradesh, India.

2 Department of Biochemistry, Osmania Medical College, Hyderabad, India.

3 Department of Biochemistry, Kurnool medical college, Kurnool, Andhra Pradesh, India.

4 Joint Director (Medical) O/o. Directorate of Medical Education, Hyderabad, India.

5 The Controller of Examinations, Kalojinarayana Rao University of Health Sciences, Warangal, Telangana, India.

Corresponding author: Dr. Ketham Veera Sudhakar, Department of Biochemistry, Viswabharathi Medical College & General Hospital, Kurnool, Andhra Pradesh, India.

E-Mail: sudhakarketham.md@gmail.com

Abstract:

Introduction: Hypomagnesemia leads to platelet agregability and also decreased function of magnesium dependant enzymes, kinases and channels regulating insulin action leading to complications, and oxidative stress is also seen because of hyperglycemia. Hence we studied the serum magnesium in patients with diabetic nephropathy.

Materials and Methods: The present study was carried out on 30 diabetic nephropathy patients, 30 normal healthy controls from government General hospital, Kurnool. 5 ml of blood is collected and centrifuged and analyzed in the same day.

Results: HbA1c level were statistically significantly increased (cases 9.04 ± 1.34 % and in the controls 5.95 ± 0.14% and P<0.001,) in diabetic nephropathy patients. to contrast to this the serum Mg levels were statistically significantly decreased in the diabetic nephropathy patients (Cases 1.66 ± 0.20 mg/dl; controls 2.25 ± 0.15 mg/dl and P<0.001).

Conclusions:  This Mg depletion is said to have a negative impact on glucose homeostasis and insulin sensitivity in diabetic nephropathy patient as well as on the development & progression of diabetic nephropathy. Early diagnosis & prompt treatment of the diabetic nephropathy can improve the quality of life & increase life expectancy.

Key Words: Mg, HbA1C, FBS, Diabetic nephropathy.

REFERENCES

  1. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 2000; 294: 1-26.
  2. Ryan MF. The role of magnesium in clinical biochemistry: an overview. Ann Clin Biochem 1991; 28: 19- 26.
  3. Rao PP, Shariff MG. Serum Magnesium Levels in Type 2 Diabetic Patients with Microalbuminuria and Normoalbuminuria. Int J Sci Stud 2015;3(4):11-15.
  4. Pham PC, Pham PM, Pham SV, Miller JM, Pham PT. Hypomagnesemia in patients with type 2 diabetes. Clin J Am Soc Nephrol. 2007;2(2):366-73.
  5. S and Swaminathan. S. Role of Magnesium in Health and Disease. Journal of Experimental Sciences 2013;4(2):32-43..
  6. Meigs JB, Mittleman MA, Nathan DM, Tofler GH, Singer DE, Murphy-Sheehy PM, et.al,. Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study. JAMA. 2000;283(2):221-8.
  7. Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated haemoglobin assay. N. Engl J Med. 1984;310:341-6.
  8. Ezra Belay Ketema, Kelemu Tilahun Kibret. Correlation of fasting and postprandial plasma glucose with HbA1c in assessing glycemic control; systematic review and meta-analysis. Arch Public Health. 2015;73:43.
  9. Helen Vlassara, Jaime Uribarri. Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both? Curr Diab Rep. 2014;14(1):453.
  10. Kerstin Nowotny, Tobias Jung, Annika Höhn, Daniela Weber, Tilman Grune. Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus. 2015;5(1):194–222.
  11. Aastha Chawla, Rajeev Chawla,  Shalini Jaggi. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum? Indian J Endocrinol Metab. 2016; 20(4):546–51.
  12. Corsonello A, Ientile R, Buemi M, Cucinotta D, Mauro VN, Macaione S, et al. Serum ionized magnesium levels in type 2 diabetic patients with microalbuminuria or clinical proteinuria. Am J Nephrol 2000; 20: 187-192.
  13. Rao PP, Shariff MG. Serum Magnesium Levels in Type 2 Diabetic Patients with Microalbuminuria and Normoalbuminuria. Int J Sci Stud 2015;3(4):11-15.
  14. McCarty MF. Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist. Med Hypotheses 2005;64:619-27.
  15. Mandon B, Siga E, Chabardes D, Firsov D, Roinel N, De Rouffignac C. Insulin stimulates Na+, Cl-, Ca2+, and Mg2+ transports in TAL of mouse nephron: Cross-potentiation with AVP. Am J Physiol 1993;265:361-9.
  16. Altura BT, Altura BM. Endothelium-dependent relaxation in coronary arteries requires magnesium ions. Br J Pharmacol 1987;91:449-51.
  17. Kim DJ, Xun P, Liu K, Loria C, Yokota K, Jacobs DR Jr, et al. Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes Care 2010;33:2604-10.
  18. Mirrahimi B, Hamishehkar H, Ahmadi A, Mirjalili MR, Agamohamadi M, Najafi A, et al. The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing. Daru 2012;20:74.
  19. S, Swaminathan. S. Role of Magnesium in Health and Disease. Journal of Experimental Sciences 2013, 4(2): 32-43.
  20. Sushma S, Devi MSK, Naveen S. The Study of Relationship Between Serum Magnesium and Glycated Hemoglobin in Clinically Uncomplicated Type-2 Diabetes Mellitus Patients. J Health Sci Res 2015;6(1);1-4.

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