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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2018.106

Type of Article: Original Research

Volume 5; Issue 4: 2018

Page No.: 603-606

DOI: 10.16965/ijims.2018.106

 

STUDY OF BIOCHEMICAL CHANGES, ANTIOXIDANT STATUS AND OXIDATIVE STRESS IN PATIENTS WITH ALCOHOLIC LIVER DISEASE

Haresingh Makwane 1, Sangeeta paneri 2, Meena Varma *1, Rajesh Kumar Jha 3.

*1, 3 Department of Biochemistry, Sri Aurobindo Institute of Medical Sciences, Indore, India.

2 Department of Biochemistry MGM Medical College Indore, India.

4 Department of Medicine, Sri Aurobindo Institute of Medical Sciences, Indore, India.

Corresponding Author: Dr. Meena Varma, Department of Biochemistry, Sri Aurobindo Institute of Medical Sciences, Indore, India. E-Mail: harshmakwane86@gmail.com

Abstract:

Introduction: Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. ALD is caused by drinking too much alcohol. A large proportion of drinkers developed fatty liver, alcoholic hepatitis and cirrhosis, the more serious types of alcoholic liver diseases due to drinking more than the recommended limits of alcohol over many years. The aim of this study was to find out the biochemical changes related to liver function, alteration in antioxidant status and oxidative stress in patient with alcoholic liver disease.

Materials and Methods: In the present study, total (n = 249) subjects were recruited from the Department of Medicine, SAIMS, Indore. 124 diagnosed cases of alcoholic liver disease, and 125 healthy control subjects. To observe the biochemical changes related to liver function measured by semi-auto analyzer. The levels of antioxidants such as SOD, CAT and oxidative stress marker; malondialdehyde (MDA) were estimated by spectrophotometric methods.

Results: The present study shown that the plasma MDA were significantly increased (p<0.001) and blood levels of SOD, CAT activity, and total protein were significantly decreased (p<0.001) in ALD as compared with group healthy controls, and also significant of biochemical parameters in study.

Conclusions: The results of this study suggested that drinking more than the recommended maximum amounts enhanced the development of ALD. Significant alteration in antioxidant levels and enhanced oxidative stress increase the severity of alcoholic liver disease.

Key words: SOD (Superoxide dismutase), CAT (Catalase), AST (Aspartate Aminotransferase), ALT (Alanine Aminotransferase), ALP (Alkaline phosphatase), GGT(Gamma Glutamyl transfererase),  Malondialdehyde (MDA), Alcoholic liver disease (ALD), oxidative stress (OS).

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