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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2018.109

Type of Article: Original Research

Volume 5; Issue 4: 2018

Page No.: 619-624

DOI: 10.16965/ijims.2018.109

 

VITAMIN D2 LEVELS IN TYPE-2 DIABETES MELLITUS PATIENTS IN ANDAMAN AND NICOBAR ISLANDS

Manasa Mekkadath Vijayan 1, Shivakrishna Gouroju *2.

1 Resident medical officer, Department of General medicine, Amrita Health center, Port Blair, Andaman, India.

*2 Tutor in Department of Biochemistry, Andaman and Nicobar Island Institute of Medical sciences, Port Blair, Andaman, India.

Corresponding author: Dr. Shivakrishna Gouroju, Tutor in Department of Biochemistry, Andaman and Nicobar Island Institute of Medical sciences, Port Blair, Andaman.

E-Mail: skgouroju@gmail.com

Abstract:

Background and Objective: Vitamin D deficiency has been recently linked to diabetes, biochemical tests are restricted to traditional monitoring of glucose. Therefore, introducing vitamin D test in Andaman and Nicobar Islands hospitals may help in the management of the disease.

Materials and methods: This case-control study comprised 30 type 2 diabetic patients (19 males and 11 females) and 30 healthy controls (18 males and 12 females) were included in the study. Serum vitamin D2, serum glucose, Glycated hemoglobin (HbA1c) was measured. Data were computer analyzed using Excl spared sheet and SPSS version 18.0.

Results: The mean ages of cases and controls were 39.9±6.84 and 37.7±9.95 years, p=0.32 respectively. The levels of blood HbA1c, Fasting blood glucose and Post Prandial Blood Glucose levels were significantly increased in cases compared to controls (9.04±1.34 vs. 5.95±0.14%, P=0.00; 178.27±32.13 vs. 91.67±13.61mg/dl, P=0.00; and 287.03±42.66 vs 124.23±8.01mg/dl, p=0.00 respectively). Vitamin D2 level were cases 9.71­±1.82 ng/ml, and controls 34.47±3.06 ng/ml were also statistically significantly decreased (p=0.00) in type -2 diabetic patients when compared with healthy controls. Vitamin D2 levels were negatively correlating with age, FBS, PPBS, and HbA1c (r=-0.284, p=0.128; r=-0.064, p=0.738; r=-0.059, p=0.757; and r= -0.077, p=0.685 respectively) in cases.

Conclusions: Serum vitamin D2 was significantly lower in type 2 diabetic patients compared to controls in Andaman and Nicobar Islands. Serum vitamin D2 was negatively correlated with Age, FBS, PPBS, and HbA1c. It’s accepted that vitamin D treatment improves insulin resistance. Therefore, supplementation of vitamin D to type 2 diabetic patients in the Andaman and Nicobar Islands hospitals and clinics may be useful in the disease management.

Key words: Type 2 diabetic patients, HbA1c, Serum vitamin D2, Andaman and Nicobar Islands.

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