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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2018.115

Type of Article: Original Research

Volume 5; Issue 6: 2018

Page No.: 644-649

DOI: 10.16965/ijims.2018.115

 

HISTOPATHOLOGICAL PROFILE OF THE GASTROINTESTINAL POLYPS IN KASHMIR VALLEY

Shaziya Ashraf 1, Syed Besina Yasin 2, Subuh Parvez Khan *3, Mushtaq Ahmad Khan 4, Farhat Abbas 5.

1 MD Pathology, Resident, Department of Pathology, Sher E Kashmir Institute of Medical Sciences Srinagar Kashmir, India.

2 MD Pathology, Additional Professor And Head of the Department, Department of Pathology, Sher E Kashmir Institute Of Medical Sciences ,Srinagar, Kashmir, India.

*3 MD Pathology,Senior Resident, Department of Haematopathology, Sher E Kashmir Institute of Medical Sciences ,Srinagar, Kashmir, India.

4 MD Internal Medicine, Dm Gastroenterology, Professor, Department of Gastroenterology, Sher E Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.

5 MD Pathology, Resident, Department of Pathology, Sher E Kashmir Institute Of Medical Sciences Srinagar Kashmir, India.

Corresponding Author: Dr Subuh Parvez Khan, MD Pathology, Senior Resident, Department of Haematopathology, Sher E Kashmir Institute Of Medical Sciences, Srinagar,  Kashmir, 190011, India. E-Mail: khansubuh@gmail.com

ABSTRACT

Introduction: A gastrointestinal (GI) polyp is a discrete mass protruding into the lumen of GI Tract  projecting above the plane of the mucosal surface .Polyp may be neoplastic and neo-neoplastic in nature. Determining the potential risk of malignancy of the polyp is very important for the purpose of line of treatment. The polyp size and histological types are important factors for development of cancers in polyps.

Materials and Methods: This was a five year observational study conducted from 2012-2016. All the patients diagnosed with true Gastro-intestinal polyps enrolled in Sher-i-Kashmir Institute of Medical Sciences, Kashmir were analyzed. Data regarding the clinico-pathological parameters was collected. Gastrointestinal polyps were grouped as per age, location, number, presence and absence of stalk, presence and absence of dysplasia; and histological type. The data was analyzed using the statistical software SPSS version V 20.

Results: Among 595 patients reported, 373 (62.7%) were males and 222 (37.3%) were females. The age of the patients ranged from 1 to 90 years.  Mean age was 40 years .Majority of the polyps ( 74%) were found in large intestine.  63.19% were non-neoplastic and  36.8% were neoplastic. 90.76% percent of the patients presented with single polyps . Sessile polyps were seen in 90.76%. Majority of cases had adenomatous polyps (36.8%), followed by  hyperplastic polyps (30.92%).  The sub types of the adenomatous polyps  were tubulovillious with 56.22 % followed by tubular and villious type with 28.31% and 15.06 %respectively. Among  adenomatous polyps, 62.10 % were with dysplasia while 37.90% were without dysplasia. Four cases of Familial Adenomatous polyposis (FAP) were observed. 15 patients presented with 9 synchronous and 6 metachronous lesions .

Conclusion: The high prevalence of adenomatous polyps in our study warrants need of screening for early detection and prevention of colorectal carcinomas. Genetic and molecular screening evaluation may also have a huge impact on understanding the mechanism of neoplastic polyps.

Key words: Polyps, Gastrointestinal, Histopathology.

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