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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2018.118

Type of Article: Original Research

Volume 5; Issue 6: 2018

Page No.: 655-658

DOI: 10.16965/ijims.2018.118

 

COMPARATIVE STUDY OF PULMONARY FUNCTION IN TYPE I AND TYPE II DIABETICS

Ratnesh N Gajbhiye 1, Mangesh A Bankar *2.

1 Associate Professor in Physiology, ANIIMS, Port Blair, India.

*2 Associate Professor in Pharmacology, ANIIMS, Port Blair, India.

Corresponding author: Dr. Mangesh A Bankar, Associate Professor in Pharmacology, ANIIMS, Port Blair, India. E-Mail: drmbankar@gmail.com

ABSTRACT:

Background: Diabetes is a disease involving almost each and every organ of our body. When blood glucose level remain chronically elevated, glycosylation of tissue proteins occur leading to irreversible changes in the chemical structure of tissue proteins. Protein containing tissues such as skin, muscles, kidneys, peripheral nerves, respiratory system, vascular bed, etc. are the prime targets for glycosylation. The functional status of the lungs can be fairly evaluated with the help of a spirometer which gives fairly good results. Present study was undertaken to compare the pulmonary functions in type I and type II diabetics. Materials and Method: 60 type I and 60 type II diabetic subjects were randomly selected for the study. Anthropometric parameters, blood investigations and spirometry was performed on all the subjects.

Result: Fasting and Post Meal blood glucose levels were higher in both the groups but were non significant when compared with each other. HbA1c% was on the higher side in both groups but was significantly higher in type I diabetics as compared to type II diabetics. All P.F.T. parameters were reduced in type I diabetics, but FVC, FEV1 and FEF 0.2 – 1.2 L were significantly reduced as compared to type II diabetics.

Conclusion: We observed a decrease in pulmonary function in all the diabetic subjects in the form of restrictive lung pathology, but the type I subjects are more severely affected than type II. Hence, we recommend regular testing of HbA₁c% and P.F.T. to find out early deterioration of lungs in diabetic patients.

Key words: Type I Diabetes, Type II Diabetes, Pulmonary Function Test, Nonenzymatic Glycosylation.

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