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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2018.119

Type of Article: Original Research

Volume 5; Issue 6: 2018

Page No.: 659-662

DOI: 10.16965/ijims.2018.119

 

EVALUATION OF LIVER ENZYMES IN PREGNANCY WITH COMPLICATIONS

Sreeman N Junagam 1, Balu Jatthavath 2.

1 Assistant Professor, Department of Biochemistry, Alluri Seetarama Raju Institute Of Medical Sciences, Eluru- West Godavari- Dt-  India.

*2 Assistant Professor, Department of pharmacology, Alluri Seetarama Raju Institute Of Medical Sciences, Eluru- West Godavari- Dt- India.

Corresponding Author: Dr. Balu Jatthavath, Assistant Professor, Department of pharmacology, Alluri Seetarama Raju Institute Of Medical Sciences, Eluru- West Godavari- Dt- India. E-Mail: drjatthavath@gmail.com

 

ABSTRACT:

Background: The hormones secreted to support foetal growth and development show effect on metabolic, synthetic and excretory function of liver in pregnancy. Complications of pregnancy added to this may aggravate and precipitate liver dysfunction. Liver dysfunction in pregnancy has serious consequences. So in this study we studied the liver function tests in normal pregnancy and complicated pregnancy, distribution of complications according to maternal age and the association of liver function to all complications of pregnancy.

Materials and Methodology: This observational cross sectional study was conducted in Alluri Seetarama Raju Institute of Medical Sciences from March 2007 to September 2007 involving 46 normal pregnant women (control Group) and 40 complicated pregnant women (study Group).

Results: We found more complications in the pregnancy with increasing maternal age i.e., after 30 years (60%), and Hyperemesis gravidarum (20%) and urinary tract infection (20%) are the most common complications found in study group. We found significantly elevated levels of SGPT (ALT) study group when compared to control group (P=0.001).

Conclusion: Elderly maternal age will result in more complications which can lead to still births and maternal mortality. Complications of pregnancy can lead to liver dysfunction which may be sometimes difficult to find out because of lack of established reference range for LFT.

Key words: Normal pregnancy, complicated pregnancy, liver function tests (LFT).

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