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ISSN: 2394-4137 (E) 2394-6318 (P)

IJIMS.2018.120

Type of Article: Original Research

Volume 5; Issue 6: 2018

Page No.: 663-666

DOI: 10.16965/ijims.2018.120

 

OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN AGRICULTURAL PESTICIDE SPRAYERS

Sreemannarayana Junagam 1, Balu Jatthavath *2.

1 Assistant Professor, Department of Biochemistry, Alluri Seetarama Raju Institute Of Medical Sciences, Eluru- West Godavari- Dt-  India.

*2 Assistant Professor, Department of pharmacology, Alluri Seetarama Raju Institute Of Medical Sciences, Eluru- West Godavari- Dt-  India.

Corresponding Author: Dr. Balu Jatthavath, Assistant Professor, Department of pharmacology, Alluri Seetarama Raju Institute Of Medical Sciences, Eluru- West Godavari- Dt-  India. E-Mail: drjatthavath@gmail.com

ABSTRACT:

Background:  In India Agriculture is the principle occupation and considerable proportion of population, farmers, females and children are exposed to harmful effects of organophosphorous pesticides, it is reported that OPIs, besides their inhibitory effect on AChE, also induce changes characteristic of oxidative stress resulting in chronic diseases. In view of the possible oxidative stress involved in OPI poisoning, we have decided to estimate the levels of antioxidant status and oxidative stress in pesticide sprayers working in paddy fields by estimating blood levels of MDA, ADA, Vitamin C and SOD levels in blood.

Materials and Methods: The study was conducted at the Department of Biochemistry, Rangaraya Medical College with 62 farmers (study Group), and 30 (control group) volunteers from in and around Kakinada were participated in the study by giving consent form. Blood collected in EDTA and plain bottles. Serum was separated and analysis was done on the same day or stored at -80oc. The observed values are compared with control group for statistical analysis by using SPSS soft ware.

Results: In our present study MDA, ADA, and SOD levels are significantly elevated in chronic organophosphorous poisoning or sprayer population in compares with control group (P < 0.001, P <0.001, and P <0.001) respectively. The vitamin C level in the blood was significant decrease in sprayer population when compared to controls (P <0.001), indicating low antioxidant status in study group.

Conclusion: Our results indicate that chronic, long term pesticide exposure will lead to change in antioxidant status and oxidative stress pattern which may result in chronic diseases.

Key words: Oxidative Stress, Antioxidant Status, Organophosphorous Insecticide, Pesticide, Sprayers.

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