Type of Article: Original Research
Volume 5; Issue 8: 2018
Page No.: 715-720
COMPARISON OF CARDIAC AUTONOMIC ACTIVITY BETWEEN OFFSPRINGS OF NORMOTENSIVE PARENTS AND HYPERTENSIVE PARENTS
Ashwani Sharma *1, Rajesh Misra 2, Kiran Singh 3.
*1 Ph.D. Scholar, Department of Physiology, Subharti Medical College, Meerut, India.
2 Professor, Department of Physiology; Principal, Shridev Suman Subharti Medical College, Dehradun, India.
3 Professor & Head, Department of Physiology, Subharti Medical College, Meerut, India.
Corresponding Author: Ashwani Sharma, Ph.D. Scholar, Department of Physiology, Subharti Medical College, Swami Vivekanand Subharti University, N.H.-58, Delhi-Haridwar Bypass Road, Meerut – 250005, Uttar Pradesh (India). E-Mail: firstname.lastname@example.org
Hypertension is a disease which affects almost entire organ systems of the body therefore it becomes essential to diagnose hypertension at an early stage so that the preventive measures can be employed. Heart Rate Variability (HRV) is used for the prediction, diagnosis and prevention of many cardiovascular dysfunctions. The aim of this study was to record basal Heart Rate (HR), Blood Pressure (BP) and HRV in offsprings of normotensive parents and hypertensive parents and compare the results between these two groups. This study was conducted on 200 subjects of age between 18 to 26 years. They were divided into two groups: control group (100; offsprings of normotensive parents) and study group (100; offsprings of hypertensive parents). The HR and BP values were measured by automatic heart rate and blood pressure measuring machine, Accusure TD 3127, Taiwan whereas HRV was recorded using RMS Polyrite D, (version 2.4), India in both the groups. Statistical analysis was done by student’s unpaired t-test using GraphPad Prism 5 software version 5.03 and P values less than 0.05 was considered to be statistically significant. The HR and BP values were high in study group in respect to control group but were not statistically significant. HRV analysis has two components: time domain and frequency domain. The values of time domain parameters were insignificantly less in study group compared to control group but only Standard Deviation of Normal-to-Normal intervals (SDNN) was found to be highly statistically significant. Among the frequency domain, Low and High Frequency in normalized units (LFnu & HFnu) were statistically higher and lower respectively in study group when compared to control group. Our results indicate that there was an increased sympathetic and decreased parasympathetic activity in the study group at resting level. These findings are an early marker of cardiovascular impairment in individuals with parental history of hypertension.
KEY WORDS: Blood Pressure, Cardiac Autonomic Activity, Heart Rate Variability.
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