IJIMS.2019.119

Type of Article: Original Research

Volume 6; Issue 5: 2019

Page No.: 839-844

DOI: 10.16965/ijims.2019.119

A STUDY ON AETIOPATHOGENESIS AND MANAGEMENT OF NASAL POLYPOSIS

R Sowmya 1, D Mahesh *2.

1 Assistant Professor in Department of ENT, Dr. Patnam Mahendar reddy Institute of Medical Sciences, Chevella, Rangareddy, Telangana, India.

*2 Civil assistant surgeon specialist in ENT, Area hospital, Kamareddy, Telangana, India.

Corresponding author name: D Mahesh, Flat no. 403, Priya residency, Mythri nagar, Madinaguda, Hyderabd-500049, India. E-Mail: s.ramarappu@gmail.com; maheshdasari6@gmail.com

ABSTRACT:

Nasal polyps are one of the most common inflammatory mass lesions of the nose. Their etiology remains unclear, but they are known to have associations with allergy, asthma, infection, fungus,cystic fibrosis, and aspirin sensitivity. However, the underlying mechanisms interlinking these pathologic conditions to nasal polyp formation remain unclear. In the present cross-sectional study was carried with 100 patients diagnosed with nasal polyposis in the age group of 10-60 years of both the sexes were studied during this period from June 2014 to October 2015 in the department of ENT, Kakatiya medical college attached to MGM Hospital, Warangal were found in large majority age groups of 11 – 30 years, men are most commonly seen affecting than women (men: women are 2:1).Allergic rhinitis is strongly associated with nasal polyposis, most common symptom is nasal obstruction, anosmia and facial pain are also seen.Most of the patients had nasal polyps reaching beyond the middle turbinate. And also, most of the patients had bilateral ethmoidalopacification on CT scan.only few showed sphenoid and frontal opacities.Steroid therapy was useful in 38% of patients.All others required endoscopic sinus surgery. Also, strong genetic factors are implicated in the pathogenesis of nasal polyps, but genetic and molecular alterations required for its development and progression are still unclear.

Key words: Allergic rhinitis,Anosmia, Facial pain, Nasal obstruction, Nasal polyposis,and Rhinorrhoea.

REFERENCES

  1. Mygind N, Lund J V, Jones R J. Nasal polyposis and Surgical management of rhinosinusitis. In: Gleeson M, Browning G G,Burton J M et al.Scott and Brown’s Otorhinolaryngology, head and neck surgery,Edward Arnold publishers Ltd 2008, 7th edition, volume 2,pp: 1549-50,1552-56,1480-1.
  2. Davidson TM, Murphy C, Mitchell M, Smith C, Light M. Management of chronic sinusitis in cystic fibrosis. Laryngoscope. 1995;105:354-8.
  3. Bachert C, Hörmann K, Mösges R, Rasp G, Riechelmann H, Müller R,  et al. An update on thediagnosis and treatment of sinusitis and nasal polyposis. Allergy. 2003 Mar;58(3):176-91.
  4. Nores JM, Avan P, Bonfils P. Medical management of nasal polyposis: a study in a series of 152 consecutive patients. Rhinology.2003;41:97-102.
  5. S.C, Endoscopic sinus surgery. In: Marks S.C.Textbook on nasal and sinus surgery, W. B.Saunders Company 2000 pp: 119,125-26,140-141.
  6. Becker SS. Surgical management of polyps in the treatment of nasal airway obstruction. Otolaryngol Clin North Am.2009;42:377–85.
  7. Bruggers S, Sindwani R. Innovations in microdebrider technology and design. Otolaryngol Clin N Am. 2009;42:781–7.
  8. Bernstein JM, Lebowitz RA, Jacobs JB. Initial report on postoperative healing after endoscopic sinus surgery with the microdebrider. Otolaryngol Head Neck Surg. 1998;118(6):800–3.
  9. Bettega S, Soccol AT, Koerner HN, Mocellin M. Epidemiological Analysis in Patients with Nasal Polyps. Int. Arch. Otorhinolaryngol. 2007;11(3):243-9.
  10. Jovicevic J, Kljajic V.Nasal polyposis and allergic rhinitis–our experience.Srp Arh Celok Lek. 2005;133:105-7.
  11. Puwankar R. Nasal Polyposis: An Update. Curr Opin Allergy Immunol. 2003;3:1-6.
  12. Slavin RG. Asthma and Sinusitis. J Allergy Clin Immunol. 1992; 90: 534-7.
  13. Staikūniene J, Vaitkus S, Japertiene LM, Ryskiene S. Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers. Medicina (Kaunas). 2008;44(4):257-65.
  14. Drake-Lee A. Nasal polyps. In: Kerr AG, editor. Scott Brown’s otolaryngology. Oxford: Butterworth Heinemann; 1997;4:1-14.
  15. Radenne F, Lamblin C, Vandezande LM, Tillie-Leblond I, Darras J, Tonnel AB, et al. Quality of life in nasal polyposis. J Allergy Clin Immunol. 1999;104(1):79-84.
  16. Lacroix JS, Zheng CG, Goytom SH, Landis B,Quinodoz S MalisDD. Histological comparison of nasal polyposis in black African, Chinese and Caucasian patients. Rhinology.2002;40:118-21.
  17. Panduranga Kamath, Mahesh Chandra Hegde, Suja Sreedharan, K. Padmanabhan. Antrochoanal polyps and allergy—A comparative study. Indian J Otolaryngol Head Neck Surg. 2002 Jan; 54(1): 7–11.
  18. Johansson L, Akerlund A, Holmberg K, Melén I, Stierna P, Bende M. Evaluation of methods for endoscopic staging of nasal polyposis. Acta Otolaryngol. 2000;120:72-6.
  19. Joe AS, Bolger EM, Kennedy DW. Nasal endoscopy:Diagnosis and management In: Kennedy DW, Bolger EM, Zinreich J Diseases of Sinuses:Diagnosis and Management Pp:127.
  20. Ullah N,Malik TL Pal MB. Surgical Management of Massive Nasal Polyps Special edition annals.2010;16.
  21. Tuncer U, Soylu L, Aydogan B, Karakus F, Akcali C. The effectiveness of steroid treatment in nasal polyposis. Auris Nasus Larynx. 2003 Aug;30(3):263-8.
  22. Garrel R, Gardiner Q, Khudjadze M, Demoly P, Vergnes C, Makeieff M, et al. Endoscopic surgical treatment of sinonasal polyposis-medium term outcomes (mean follow-up of 5 years). Rhinology. 2003 Jun;41(2):91-6.
  23. Fokkens W, Lund V, Mullol J. European Position Paper on Rhinosinusitis and Nasal Polyps Group. Rhinology. 2007; 45(2):97-101.

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